New research into the cellular clearance pathways governed by the GBA gene has shown reduced activity associated with both ageing and idiopathic Parkinson’s.
A new preclinical study has shown that LRRK2 inhibition in an animal model of Parkinson’s can improve lysosomal health and reduce alpha synuclein accumulation in dopaminergic neurons.
Largest UK population based study of PD found up to 10% of affected individuals carry a pathogenic mutation
PINK1 may also protect cells and the brain from autoimmune attack
Changes in smell, mood, and cognition in people with GBA1 mutations
Using the largest ever genetics dataset