These ‘articles in a nutshell’ provide a balanced, straightforward and realistic overview of new science in Parkinson’s, and what it really means in the context of moving towards a cure.
Understanding urinary problems in Parkinson’s
In a large survey by the Parkinson Alliance, 41% of the participating people with Parkinson’s reported that urinary symptoms impact on their
Exosomes 2
Alpha synuclein found in exosomes has been shown to differentiate Parkinson’s from other related conditions, outperforming previous ways of
Living with Parkinson’s during the COVID-19 outbreak
Information and advice on how to take care of yourself and your Parkinson’s during the COVID-19 outbreak
Precision Medicine
Precision medicine aims to define and treat Parkinson’s by tailoring the right therapy to each person, depending not only on their specific signs and symptoms, but also on the specific molecular signatures of their disease.
UPDRS: how reliable is it as a measure of Parkinson’s?
Study has shown UPDRS not uniformly reliable as tool for measurement of PD
Tracking serotonin in earliest stages of Parkinson’s
Serotonin changes seen before dopamine changes in people with A53T SNCA mutation.
An olfactory signature for Parkinson’s?
Compounds found in sebum of PwPs could form non-invasive test
Alpha-synuclein roadmap
Guiding the discovery of therapies targeting a-synuclein.
AUDIO VERSION AVAILABLE.
The immune system in Parkinson’s
Innate and the adaptive immune system responses
Under-representation of women in trials
Need to bridge the gender gap in Parkinson’s research emerges.
AUDIO VERSION AVAILABLE
Caffeine and Parkinson’s
The Harvard Biomarkers Study has found that people who consume more caffeine and have higher
Parkinson’s in Women and Men: recognising the differences
Parkinson’s affects women and men differently. This is reflected both in their different clinical features and progression, as well as in their experience of the condition.
Changes in gait can predict conversion to Parkinson’s
Study found gait characteristics which predict conversion to PD
Effects of gut bacteria on L-Dopa: revealing the inner pharmacist
Gut bacteria and pathway for processing of oral L-Dopa discovered
RBD Sleep and Parkinson’s
Research into early sleep problems predicting Parkinson’s
New molecular target SCD
Targeting key enzyme reduced a-synuclein accumulation
Appendix and Parkinson’s risk
Abnormally folded alpha-synuclein found in appendices.
AUDIO VERSION AVAILABLE.
Retinal thickness as a Parkinson’s biomarker
Link between retinal thickness and dopaminergic cell loss
Insulin resistance in early Parkinson’s
Insulin resistance in non-diabetic people with Parkinson’s
Cardiolipin and mitochondria dysfunction
Mitochondrial phospholipid and a-synuclein link
Evidence for immune changes in early Parkinson’s
Immune cells responsive to alpha synuclein were found in two different groups of
Deep phenotyping of peripheral tissue in Parkinson’s
Skin cells have been used to characterize specific cellular problems in people with Parkinson’s, in a new approach that may help match them to particular drugs that may work best for them.
Modelling the evolution of PD from gut to brain
New animal model of PD shows misfolded alpha synuclein can spread from gut to brain.
AUDIO VERSION AVAILABLE.
The beneficial effects of a flavonoid found in honey
The neuroprotective effects of a flavonoid found in honey
Understanding Levodopa
Long term Levodopa-induced dyskinesias in Parkinson’s
Clusters of Parkinson’s: subtypes
Study has highlighted four clusters/sub-groups of patients
Triggers, Facilitators and Aggravators
New hypothesis which could reconceptualise Parkinson’s
Metabolic syndrome increases PD risk
Metabolic syndrome components increase risk for Parkinson’s
Breath testing for early detection
Possibile novel method for early detection and diagnosis
Trophic Factors in Parkinson’s
Regeneration of the axon no longer dismissed as impossible.
AUDIO VERSION AVAILABLE.
